Experimental Ischemic Stroke–Induced Alpha-Synuclein Pathology Enhances Endothelial Inflammatory Response and Impairs Angiogenesis
These findings indicate that ischemia-triggered pathological α-Syn leads to worse outcome in stroke mice by promoting endothelial inflammatory response and immune cell infiltration during the acute phase and by limiting angiogenesis in the subacute phase.
Authors
- Alessia Valente (ORCID: https://orcid.org/0000-0002-6917-9278)
- Arianna Bellucci (ORCID: https://orcid.org/0000-0002-9581-1919)
- Gaia Faustini (ORCID: https://orcid.org/0000-0002-0751-3082)
- Tizibt Ashine Bogale (ORCID: https://orcid.org/0000-0002-0905-2654)
- Serena Seminara
- Marina Pizzi (ORCID: https://orcid.org/0000-0002-4857-5204)
- Stefania Maria Filomena Mitola (ORCID: https://orcid.org/0000-0002-5557-738X)
- Domenico Mercurio (ORCID: https://orcid.org/0000-0001-5101-7222)
- Francesca Longhena (ORCID: https://orcid.org/0000-0001-6569-9412)
- Aurora Bianchi
- Stefano Fumagalli (ORCID: https://orcid.org/0000-0003-3598-6263)
Institutions
- Mario Negri Institute for Pharmacological Research (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Stroke
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1161/strokeaha.125.052265
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00