Integrative metabolomic and proteomic analysis of diabetic kidney disease progression with younger‐onset type 2 diabetes
Lower plasma BCAA levels are independently associated with DKD progression in YT2D. Integrative multi-omics analysis highlights disruptions in metabolic and apoptotic pathways, providing insights into DKD pathophysiology and potential biomarkers for early risk stratification.
Authors
- Huili Zheng (ORCID: https://orcid.org/0000-0002-3976-0088)
- Keven Ang (ORCID: https://orcid.org/0000-0002-7656-2523)
- Tavintharan Subramaniam (ORCID: https://orcid.org/0000-0002-5365-8899)
- Clara Tan
- Clara C. Chan (ORCID: https://orcid.org/0000-0002-2886-2011)
- Jensen C. C. Tan (ORCID: https://orcid.org/0000-0003-1856-5694)
- Resham L Gurung (ORCID: https://orcid.org/0000-0002-8772-4452)
- Chee Fang Sum (ORCID: https://orcid.org/0000-0003-3532-0568)
- Jianjun Liu
- Su Chi Lim (ORCID: https://orcid.org/0000-0003-1742-5817)
- Sylvia Liu (ORCID: https://orcid.org/0000-0001-8561-7787)
Institutions
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Khoo Teck Puat Hospital (SG)
- National University Health System (SG)
- Signature Research (United States) (US)
- Clinical Nutrition Research Centre (SG)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/dom.70153
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35