Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity
Such SAE-based radiopharmaceuticals provide a candidate platform to elevate TRT efficiency, and the proof-of-concept rationale of disrupting lipid metabolic homeostasis through multienzyme-mimicking cascade reactions also provides a general avenue to improve TRT and synergistically magnify antitumor immunity.
Authors
- Shanshan Qin (ORCID: https://orcid.org/0009-0003-1722-0392)
- Yang Gao (ORCID: https://orcid.org/0000-0003-3209-4788)
- Mengdie Yang (ORCID: https://orcid.org/0000-0002-6390-2728)
- Jia-Jia Zhang
- Yi Zhun Zhu (ORCID: https://orcid.org/0000-0001-7700-8041)
- Kun Zhang (ORCID: https://orcid.org/0000-0002-6971-1164)
- Xiaoyi Zhang (ORCID: https://orcid.org/0009-0006-8530-0089)
- Miao Chen (ORCID: https://orcid.org/0000-0003-2337-8770)
- Chao Ma (ORCID: https://orcid.org/0000-0001-6980-5833)
- Fei Yu (ORCID: https://orcid.org/0000-0002-7812-1203)
- Ling Bai
- Chunyan Zhu (ORCID: https://orcid.org/0000-0002-3434-2581)
Institutions
- Duke University (US)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1186/s40779-025-00647-7
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04