Sex-Specific Association Between XPC rs2228001 Polymorphism and Parkinson’s Disease Risk in a Mexican Population: A Case–Control Study Exploring Gene–Environment Interactions
Our findings suggest a sex-specific genetic contribution to PD susceptibility involving the <i>XPC</i> rs2228001 variant, particularly in the context of pesticide exposure. These results underscore the relevance of DNA repair pathways in PD pathogenesis and highlight the importance of integrated models incorporating genetic and environmental risk factors.
Authors
- Daniel Francisco Ramos-Rosales (ORCID: https://orcid.org/0000-0003-4109-267X)
- Sergio Manuel Salas-Pacheco (ORCID: https://orcid.org/0000-0001-7123-8751)
- Jose Manuel Salas-Pacheco (ORCID: https://orcid.org/0000-0002-8256-2239)
- Osmel La Llave-León (ORCID: https://orcid.org/0000-0003-2788-3344)
- Edna Madai Méndez-Hernández (ORCID: https://orcid.org/0000-0002-8143-9001)
- Gerardo Quiñones-Canales
- Francisco X. Castellanos-Juárez (ORCID: https://orcid.org/0000-0002-5570-3817)
- Alma Cristina Salas-Leal (ORCID: https://orcid.org/0000-0002-1849-0998)
- Ada Agustina Sandoval-Carrillo (ORCID: https://orcid.org/0000-0002-4727-3730)
- Elizabeth Irasema Antuna-Salcido
- Óscar Arias-Carrión (ORCID: https://orcid.org/0000-0002-9982-7571)
- Karla Mariana Alvarado-Retana
Institutions
- Universidad Juárez del Estado de Durango (MX)
- Instituto Nacional de Rehabilitación (MX)
- Hospital Universitario Ramón y Cajal (ES)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3390/brainsci15091008
- Citations
- 1
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado