Comparative Mapping of N6-Methyladenine, C5-Methylcytosine, and C5-Hydroxymethylcytosine in a Single Species Reveals Constitutive, Somatic- and Germline-Specific, and Age-Related Genomic Context Distributions and Biological Functions
We observed that 6mA, 5mC, and 5hmC displayed constitutive, somatic- and sperm-specific, and age-related differences that were associated with distinct genomic contexts and biological functions, supporting the complementarity of these methylation marks and their diverging epigenetic roles.
Authors
- Serge Aron (ORCID: https://orcid.org/0000-0002-1674-8828)
- Thibaut Renard (ORCID: https://orcid.org/0000-0002-7796-3986)
Institutions
- Université Libre de Bruxelles (BE)
Publication Details
- Journal
- Epigenomes
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3390/epigenomes9030035
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00