Functional loss of <scp>CHS2</scp> confers high‐level resistance to <scp> <i>Bacillus thuringiensis</i> Vip3Aa </scp> in <scp> <i>Spodoptera exigua</i> </scp> and <scp> <i>Agrotis ipsilon</i> </scp>
These findings further validate the essential role of the CHS2 gene-and the PM it produces-in Vip3Aa toxicity. Complete knockout confers high resistance but imposes severe fitness costs, suggesting that such alleles are unlikely to persist in natural populations. This study advances our understanding of the molecular mechanisms behind resistance to Vip3Aa and provides insights for developing effective resistance management strategies in Bt crop management. © 2025 Society of Chemical Industry.
Authors
- Kaikai Mao
- Luming Zou (ORCID: https://orcid.org/0000-0003-2302-637X)
- Yiping Li (ORCID: https://orcid.org/0000-0002-9461-813X)
- Yutao Xiao (ORCID: https://orcid.org/0000-0003-3203-9375)
- Peng Wang (ORCID: https://orcid.org/0000-0002-0322-7038)
- Zhenxing Liu (ORCID: https://orcid.org/0000-0001-9371-6929)
- Hui Yao (ORCID: https://orcid.org/0000-0002-7800-0858)
- Chongyu Liao (ORCID: https://orcid.org/0000-0002-6821-6217)
- Qiangqiang Kang
Institutions
- Guangxi University (CN)
- Agricultural Genomics Institute at Shenzhen (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Ministry of Agriculture (CZ)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1002/ps.70226
- Citations
- 1
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.81