Advanced glycation end products mediated diabetic neuropathic pain via activation protein tyrosine phosphatase <scp>1B</scp> in the spinal cord dorsal horn
These findings suggest that elevated plasma AGEs contribute to hyperalgesia through a PTP1B-dependent mechanism involving Src/NMDAR signalling in the spinal dorsal horn. Targeting the AGEs-PTP1B-NMDAR pathway may offer new therapeutic strategies for managing DNP.
Authors
- Shu‐Jin Wu
- Z.M. Zhang (ORCID: https://orcid.org/0009-0000-5232-8129)
- Qingshan Yang (ORCID: https://orcid.org/0000-0002-3925-0344)
- Ruihong Sun (ORCID: https://orcid.org/0000-0002-9843-707X)
- Wenjing Li (ORCID: https://orcid.org/0000-0003-4535-8623)
- Xiaoqin Li (ORCID: https://orcid.org/0000-0003-3762-9817)
- Ye Shen (ORCID: https://orcid.org/0000-0001-5235-0182)
- Jing Wang (ORCID: https://orcid.org/0000-0002-2781-7753)
- Yu‐Hang Yang
- Jiajia Wang (ORCID: https://orcid.org/0000-0001-8559-7501)
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Ningxia Medical University (CN)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/dme.70141
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16