Cross-Sectional Study on Behavioral Abnormalities and Quality of Life in Children with Idiopathic Nephrotic Syndrome Following Corticosteroid Therapy

One of the kidney diseases that affect children the most frequently is idiopathic nephrotic syndrome. The most common treatment is corticosteroid medication. However, repeated or prolonged use of corticosteroids has been linked to negative effects, behavioral abnormalities, and a decline in children›s quality of life. The purpose of the current study was to evaluate the degree and type of behavioral aberrations and their effect on quality of life in children receiving corticosteroid therapy for idiopathic nephrotic syndrome. This cross-sectional survey was conducted in tertiary care facilities across Lahore, Pakistan, between March and June two thousand twenty-five. Included were two hundred fifty children aged six to eighteen years diagnosed with idiopathic nephrotic syndrome undergoing corticosteroid therapy. Data was gathered using validated tools, such as the Pediatrics Quality of Life Inventory version four point zero for physical, emotional, social, and school-related quality of life, and the Child Behavior Checklist for behavioral symptoms. Data was analyzed using Statistical Package for the Social Sciences and Stata software to identify statistically significant behavioral predictors through logistic regression models. Twenty-one of thirty behavioral symptoms showed significant differences, with younger children experiencing more issues such as arguing, low enjoyment, and cruelty to animals. These behaviors were strong predictors. Academic performance, emotional well-being, and physical health all declined, while social functioning remained largely unaffected. The findings show that children with idiopathic nephrotic syndrome on corticosteroids face reduced quality of life and recurring behavioral problems. Psychological support should be integrated with medical treatment.