Discovery of Novel 1,3,4-oxadiazole-based Inhibitors Against Urease and Diabetes: Design, Synthesis, SAR, Biological, and Molecular Docking Screening
The synthesized 1,3,4-oxadiazole derivatives demonstrate promising dual inhibitory activity against urease and α-glucosidase, suggesting their potential as lead compounds in the treatment of gastric infections and diabetes. This study contributes to the ongoing development of multifunctional therapeutic agents with improved efficacy and selectivity.
Authors
- Aneela Maalik (ORCID: https://orcid.org/0000-0002-1124-0873)
- Wajid Ur Rehman (ORCID: https://orcid.org/0000-0003-0128-0377)
- Mohammed B. Hawsawi (ORCID: https://orcid.org/0000-0003-1527-5560)
- Majed Alharbi (ORCID: https://orcid.org/0000-0002-7084-5901)
- Liaqat Rasheed (ORCID: https://orcid.org/0000-0003-3602-6803)
- Yousaf Khan (ORCID: https://orcid.org/0000-0001-5455-7849)
- Mustafa S. Alluhaibi (ORCID: https://orcid.org/0009-0007-3756-2874)
- Sabeen Arshad
- Hina Sarfraz (ORCID: https://orcid.org/0009-0002-1497-8096)
Institutions
- Quaid-i-Azam University (PK)
- COMSATS University Islamabad (PK)
- King Abdulaziz University (SA)
- Umm al-Qura University (SA)
- Hazara University (PK)
- Henan University of Technology (CN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-09-16
- DOI
- https://doi.org/10.2174/0115734064385863250815045326
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00