ON THE POSSIBILITY OF COMBINING DIMETHYLAMINOETHANOL WITH SODIUM SUCCINATE IN A SINGLE DOSAGE FORM

Іntroduction. In recent times, cognitive impairments have spread significantly due to many factors, in particular, due to the beginning of full-scale armed aggression by the Russian Federation. The creation of new effective and safe combined medicines with dimethylaminoethanoland sodium succinate is a crucial task of modern medicine and pharmacy. For co-use of dimethylaminoethanol and sodium succinate, it is necessary to study their physicochemical properties.Purpose of the work is to study the possibility of combining dimethylaminoethanol with sodium succinate in one dosage form.Materials and methods. The object of study is dimethylaminoethanol and sodium succinate. The crystallographic properties of the substances were studied according to the SPhU using optical crystallography and photomicrography using a Ulab XY-B2T LED microscope (China). Thermogravimetric analysis was carried out on derivatograph: “ShimadzuDTG-60” derivatograph (Japan) with a platinum-platinumrhodium thermocouple while heating the samples in aluminum crucibles (temperature regime from 17 to 200ºС).Results. The study of the crystallographic properties of dimethylaminoethanol and sodium succinate made it possible to predict the possibility of their combination in one dosage form. Thanks to the further study of the physical and chemical properties of dimethylaminoethanol and sodium succinate using thermogravimetric analysis, it was found that they are thermally stable compounds. According to the results of theobtained derivatograph data, production of the dosage form should take place at a temperature not higher than 105ºС.Conclusions. According to the crystallography and derivatograph study of dimethylaminoethanol and sodium succinate substance and the mixture of dimethylaminoethanol-sodium succinate, it should be noted that the mixture of dimethylaminoethanol and sodium succinate is a mixture of active substances that do not interact with each other and can be in the same dosage form in the form of tablets obtained by the direct compression, or sachets.