CYTOKINE CHANGES IN PERIODONTITIS AND UNDER THE CONDITIONS OF USING DIFFERENT TYPES OF REMOVABLE PROSTHETIC BASES

The study of the mechanisms of the development of inflammatory processes in periodontal tissues remains relevant due to the high prevalence of this pathology, its unfavorable prognosis, as well as the limited effectiveness of treatment and prevention.The aim of the work – to investigate changes in cytokine status in experimental bacterial-immune periodontitis and under the conditions of using acrylic and nylon prosthetic bases.Materials and methods. Experimental bacterial-immune periodontitis in animals was induced by injecting a mixture of microorganisms suspended in egg protein into the periodontal tissue. By the 30th day, the blood serum was then collected for subsequent analysis, and the levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and interleukin-10 (IL-10) were determined using the solid-phase enzyme immunoassay method.Results and discussion. Modelled bacterial-immune inflammation on the 30th day of the study, which was characterized by the most pronounced clinical manifestations of periodontitis, there was a reactive increase in the level of pro-inflammatory cytokines in the blood serum and a decrease in the level of the anti-inflammatory cytokine. Fixation of prosthetic bases made of different types of plastics under conditions of experimental periodontitis contributed to an increase of the inflammatory process in the periodontum. This was manifested by an increase in the level of pro-inflammatory cytokines, as well as a decrease in the concentration of anti-inflammatory interleukin-10 in blood serum.Conclusion. An increase of IL-1β and IL-6 and a decrease of IL-10 when using acrylic bases, in comparison with nylon, indicates a smaller negative impact of nylon plastic on the development and course of inflammation in periodontal tissues.