Use of primary oral vancomycin prophylaxis to stem an outbreak of <i>Clostridioides difficile</i> infection in intensive care patients
Over 5.5-months, hospital-onset <i>Clostridioides difficile</i> infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days (<i>P</i> = .03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days (<i>P</i> = .05). Primary OVP curbed an outbreak of HO-CDI.
Authors
- Daniel Rampersad
- Anjali Kewalramani
- John Quale (ORCID: https://orcid.org/0000-0001-6043-4298)
- Shaurya Sharma (ORCID: https://orcid.org/0000-0001-6039-5735)
- Briana Episcopia (ORCID: https://orcid.org/0000-0002-9767-8672)
- Zhong Qu
- Leon Boudourakis
- Katrina Sandejas
Institutions
- New York City Health and Hospitals Corporation (US)
- Kings County Hospital Center (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10095
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00