Alternative Therapy of Menopausal Syndrome from the Perspective of Comprehensive Aging Prevention

Aim. To systematize data on optimal forms of delivery of the resveratrol molecule, its dosages, bioavailability, combined regimens and possible side effects when used to slow down aging in women during the menopausal transition. Key points. Every year in the Russian Federation, more than 1 million women enter menopause. Climacteric syndrome as a complex of vasomotor, psychoemotional, musculoskeletal disorders due to estrogen deficiency leads to a decrease in the quality of life of women over 40 years old. Within the framework of the review article, an assessment of modern non-hormonal methods for correcting climacteric syndrome was carried out. Among the new generation of phytoestrogens, trans-resveratrol stands out significantly; we considered the multitarget properties of the molecule from the standpoint of slowing down aging. Conclusion. The use of phytoestrogens has wide possibilities in personalized menopausal phytotherapy, the strategy of increasing the bioavailability of new phytotherapy technologies is able to influence estrogen-deficient conditions of women with greater efficiency. Transresveratrol in sublingual form is a unique solution for the correction of climacteric syndrome due to its high bioavailability, in this form it bypasses liver metabolism. The ability of trans-resveratrol to modulate estrogen-dependent pathways, suppress oxidative stress and systemic inflammation allows to effectively reduce the severity of vasomotor symptoms, improve cognitive functions and slow down involutional processes. Sublingual administration ensures rapid achievement of therapeutic concentrations and potentiates geroprotective effects, which makes this form of the drug promising for complex anti-aging therapy in women in menopause. Keywords: phytoestrogens, menopausal syndrome, postmenopause, trans-resveratrol, geroprotective effect.