Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

This study reveals a considerable potential to reduce the ADOD burden in many countries. Although some metrics have stabilized or slowed in growth, significant inequalities remain, particularly in lower-SDI nations. Tailored strategies focusing on strengthening healthcare systems, targeting high-risk populations, and improving health education are essential to narrow these gaps. Greater international collaboration and open data sharing are also key to building a life-course management model for ADOD prevention and care, ultimately improving global health.