Shared molecular mechanisms between type 2 diabetes and thyroid cancer: integrated bioinformatics insights for prognostic biomarker discovery
T2D and TC exhibit overlapping genetic dysregulation, particularly in pathways governing metabolic reprogramming and tumor microenvironment crosstalk. Notably, PRDM1 and ZFPM2 may serve as therapeutic targets for TC in patients with concurrent diabetes.
Authors
- Chuankai Chen
- Chuanzhi Chen (ORCID: https://orcid.org/0009-0004-9244-078X)
- Jiahui Qi (ORCID: https://orcid.org/0000-0001-5235-0027)
- Yue Wang (ORCID: https://orcid.org/0000-0001-5530-9994)
- Feng Zhu (ORCID: https://orcid.org/0000-0002-7301-4281)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1530/ec-25-0181
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00