Association of vitamin D deficiency with insulin resistance among type 2 diabetes mellitus patients - A case-control study

The association between vitamin D deficiency and insulin resistance is of interest. Hence, 140 participants-70 type 2 diabetes mellitus (T2DM) patients and 70 age- and sex-matched healthy controls were evaluated. Serum 25(OH) vitamin D levels and HOMA-IR scores were measured and compared. Vitamin D levels were significantly lower and HOMA-IR significantly higher in T2DM patients compared to controls. An inverse correlation was observed between vitamin D levels and insulin resistance. Thus, we show a potential role of vitamin D deficiency in the pathophysiology of insulin resistance in T2DM.