Cytogenetic and molecular characterization of an atypical ETP-ALL case with BCL2 dependency: therapeutic implications for Venetoclax use
This case highlights the role of clonal evolution and immune deregulation in accompanying BCL2 addiction in relapsed ETP-ALL. Altogether, our findings underscore the therapeutic potential of venetoclax in refractory pediatric ETP-ALL cases with progressive BCL2 dependency.
Authors
- Francesco Trapasso (ORCID: https://orcid.org/0000-0001-9098-3191)
- Roberta Torcasio
- Maria Eugenia Gallo Cantafio (ORCID: https://orcid.org/0009-0009-9937-0565)
- Rodolfo Iuliano (ORCID: https://orcid.org/0000-0002-8524-7402)
- Maria Concetta Galati
- Salvatore Audia (ORCID: https://orcid.org/0009-0000-8145-8686)
- Rosario Amato (ORCID: https://orcid.org/0000-0001-7162-1099)
- Paola Malatesta (ORCID: https://orcid.org/0000-0001-9982-7769)
- Carolina Brescia (ORCID: https://orcid.org/0009-0009-8079-8086)
- Renato Cantaffa
- Francesco Gigliotti (ORCID: https://orcid.org/0000-0003-4608-2059)
- Nicola Amodio (ORCID: https://orcid.org/0000-0001-6061-626X)
- Giuseppe Viglietto (ORCID: https://orcid.org/0000-0003-2327-7515)
- Eulalia Galea
- Michelle-Li Bellisario
Institutions
- Magna Graecia University (IT)
- Dulbecco Telethon Institute (IT)
- Azienda Ospedaliero-Universitaria "Renato Dulbecco" (IT)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1007/s11033-025-10979-1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione Cassa di Risparmio di Calabria e Lucania
- Associazione Italiana per la Ricerca sul Cancro