α-Amylase-Mediated Antibiotic Degradation and Sequestration in Pseudomonas aeruginosa Biofilm Therapy
This study suggests that α-amylase is capable of degrading and sequestering a variety of antibiotics, and the degree to which these phenomena occur varies depending upon the source of the GH. As a potential treatment for biofilm-associated infections, it is imperative that the GH + antibiotic combinations are determined compatible prior to clinical use.
Authors
- Sarah Zipkowitz (ORCID: https://orcid.org/0000-0003-1005-331X)
- Nusrat Jahan (ORCID: https://orcid.org/0000-0001-7651-265X)
- Whitni K. Redman (ORCID: https://orcid.org/0000-0002-8203-1446)
- Tony D. Davis (ORCID: https://orcid.org/0000-0001-5629-7075)
- Angela Siqueira Furtado Martin
- Robert W. Murray
Institutions
- Binghamton University (US)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3390/antibiotics14090941
- Citations
- 2
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 1.61