Radical Addition-Induced Dearomative Spirocyclization/1,4-Alkyloximation of Unactivated Arenes
Nitrogenated spirocycles, as integral structural cores of numerous bioactive molecules, are valuable yet synthetically challenging three-dimensional scaffolds. Herein, we report a radical addition-induced dearomative spirocyclization/1,4-alkyloximation of unactivated arenes. The multicomponent protocol concurrently breaks the stable aromatic system and introduces multiple functional groups to synthesize highly decorated nitrogenated spirocycles via a radical cascade process.
Authors
- Chao Xie (ORCID: https://orcid.org/0000-0001-6197-2506)
- Dayong Shi (ORCID: https://orcid.org/0000-0001-8941-5285)
- Zhenchao Wang (ORCID: https://orcid.org/0009-0008-8127-1182)
- Chao Liu (ORCID: https://orcid.org/0000-0001-6368-3986)
- Cong Shi (ORCID: https://orcid.org/0009-0000-5681-3834)
- Hongyun Qin (ORCID: https://orcid.org/0000-0003-4531-8330)
- Ruihua Liu (ORCID: https://orcid.org/0000-0003-4426-9696)
- Jiashu Chen (ORCID: https://orcid.org/0000-0003-3222-1628)
- Yue Xu (ORCID: https://orcid.org/0000-0001-5953-4830)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0003-4264-7665)
- Nan Zhou
- Xiangqian Li
Institutions
- Shandong University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1021/acs.orglett.5c03231
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74