Balancing benefit and burden: treatment intensification in paediatric KMT2A rearrangements acute myeloid leukaemia
KMT2A-r is an independent prognostic factor for relapse, and presence of ACA and a complex karyotype in KMT2A-r patients is associated with poorer outcomes, emphasising the need for aggressive and innovative therapeutic strategies.
Authors
- Leslie Lehmann (ORCID: https://orcid.org/0000-0001-5558-4830)
- Mariam Elsherif
- Sherine Salem (ORCID: https://orcid.org/0000-0002-9799-9687)
- Alaa Elhaddad (ORCID: https://orcid.org/0000-0003-3538-5038)
- Reham Khedr (ORCID: https://orcid.org/0000-0001-5355-8225)
- Mohamed Kamal (ORCID: https://orcid.org/0009-0001-0984-2402)
- Hend Fayez (ORCID: https://orcid.org/0000-0001-5377-9124)
- Amr Elnashar (ORCID: https://orcid.org/0000-0001-7313-0269)
- Nahla El-Sharkawy
- Sonia Ahmed (ORCID: https://orcid.org/0000-0002-8322-4194)
Institutions
- Cairo University (EG)
- Dana-Farber Cancer Institute (US)
- Children Cancer Hospital (EG)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2025-09-18
- DOI
- https://doi.org/10.2340/1651-226x.2025.43878
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00