Systemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related Maculopathies
In rhesus macaques, soft drusen are extracellular lipid deposits associated with older age, while punctate dots are intracellular lipids linked to age, hyperglycemia, and hyperlipidemia, suggesting differential dysregulation of lipid transport in these NHP models of AMD.
Authors
- Sara M. Thomasy (ORCID: https://orcid.org/0000-0001-5617-9677)
- Kevin Choy (ORCID: https://orcid.org/0000-0002-4306-2549)
- Sina Farsiu (ORCID: https://orcid.org/0000-0003-4872-2902)
- Glenn Yiu (ORCID: https://orcid.org/0000-0003-3061-3310)
- Karolina Roszak
- Peter J. Havel (ORCID: https://orcid.org/0000-0003-3652-8301)
- Tzu-Ni Sin (ORCID: https://orcid.org/0000-0001-9282-9999)
- Leon Huynh
- Jung Ho Heo (ORCID: https://orcid.org/0000-0002-6491-2426)
- Mingming Gong
- Sophie M. Le
- Tao Shen (ORCID: https://orcid.org/0000-0002-2261-5300)
- James Graham
- Carol Villafuerte-Trisolini
- Ana Santos Raposo
Institutions
- Duke University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1167/iovs.66.12.41
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00