Highly selective 1,4-NADH regeneration <i>via</i> hydrogenated NAD<sup>+</sup> analogs using a Pt/SiO<sub>2</sub> catalyst with low pressure hydrogen gas
The hydrogenation of nicotinamide analogs using a Pt/SiO<sub>2</sub> catalyst, followed by hydride transfer to NAD<sup>+</sup>, results in the highly selective regeneration of 1,4-NADH. <i>N</i>-Methyl nicotinamide exhibits the highest reactivity, achieving 98% selectivity at 20 °C under 1 atm H<sub>2</sub>. This strategy provides a practical and sustainable pathway for 1,4-NADH regeneration.
Authors
- Yutaka Amao (ORCID: https://orcid.org/0000-0001-8575-2591)
- Wataru Onodera
- Masazumi Tamura (ORCID: https://orcid.org/0000-0002-8293-6093)
- Makoto Hirano
Institutions
- Kyoto University (JP)
- Osaka City University (JP)
- Osaka Metropolitan University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04253d
- Primary Topic
- Nanomaterials for catalytic reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00