LINC02099 Promotes Retinal Extracellular Matrix Deposition in Diabetic Mice Via the miRNA-214-3p/CTSS Axis
This study establishes the LINC02099/miRNA-214-3p/CTSS axis as a novel regulatory mechanism in PDR-associated retinal ECM expression. Targeting this pathway may provide new therapeutic strategies for managing PDR and enhancing outcomes for patients with advanced diabetic retinopathy.
Authors
- Yuqing Feng (ORCID: https://orcid.org/0000-0002-7742-5272)
- Yi Bao (ORCID: https://orcid.org/0000-0002-8882-7891)
- Angela Y. Jia (ORCID: https://orcid.org/0000-0002-0812-2614)
- Zhiming He (ORCID: https://orcid.org/0000-0001-5900-7600)
- Huiling Li (ORCID: https://orcid.org/0000-0003-3465-4187)
- Zhou Li (ORCID: https://orcid.org/0000-0002-2746-4812)
- Jinfang Lu
- Xujun Peng (ORCID: https://orcid.org/0000-0001-9373-7092)
Institutions
- Central South University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1167/iovs.66.12.42
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00