The Role of Connexin 36 Gap Junctions in Retinal Ganglion Cell Death After Corneal Alkali Burns
Our findings indicate that Cx36 gap junctions mediate secondary cell death of RGCs following corneal alkali injuries and may serve as a potential target for neuroprotective therapy. The gap junction antagonist MFA, a US Food and Drug Administration (FDA)-approved drug, could prevent this secondary cell death, highlighting its potential as a therapeutic intervention.
Authors
- ChunTing Qiu
- Chunghim So (ORCID: https://orcid.org/0000-0002-7439-5741)
- Feng Pan (ORCID: https://orcid.org/0000-0002-5256-4380)
- Ting Zhang (ORCID: https://orcid.org/0009-0002-1095-0977)
- Kangyi Yang
- Qin Wang (ORCID: https://orcid.org/0009-0004-6997-0678)
Institutions
- Hong Kong Polytechnic University (HK)
- Shenzhen Polytechnic University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1167/iovs.66.12.43
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00