Investigating the Effects of Doxorubicin and Endothelial c-Myc Deficiency on Heart Metabolism using Fluorescence Cryo-Imaging
Using a conditional mouse model and fluorescence cryo-imaging, this study investigates endothelial c-Myc's role in heart metabolism during doxorubicin treatment. NADH/FAD redox ratio analysis revealed significant differences between genotypes, while no significant difference was found between saline and doxorubicin treatments.
Authors
- Mehrnoosh Neghabi (ORCID: https://orcid.org/0000-0003-1256-4770)
- Aline G. Santana (ORCID: https://orcid.org/0000-0001-6191-4146)
- Mahsa Ranji (ORCID: https://orcid.org/0000-0002-4185-5676)
- Busenur Ceyhan (ORCID: https://orcid.org/0009-0001-8549-2846)
- Cláudia O. Rodrigues (ORCID: https://orcid.org/0000-0002-8416-3602)
- Parisa Nategh (ORCID: https://orcid.org/0009-0009-2974-7742)
- J Machi
Publication Details
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1364/cleo_at.2025.aa109_6
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00