Abstract A072: Biobanking healthy tissue in the Susan G. Komen tissue bank: Comparing Indiana and non-Indiana residents

Abstract Background: The Susan G. Komen Tissue Bank (KTB) at the Indiana University Simon Comprehensive Cancer Center is a unique biorepository of normal breast tissue. From the start, the KTB sought to recruit a wide range of women to mirror the demographics of the United States (US). To do so, the KTB has traveled across the US to collect healthy breast tissue from volunteer donors who do not have/have not developed breast cancer. Understanding the demographic and clinical characteristics of KTB participants is vital for contextualizing research findings and ensuring equitable representation in breast cancer research. Methods: We conducted a cross-sectional analysis of 4,991 KTB participants recruited from 2007-2023, comparing Indiana (n=3,819; 76.52%) and non-Indiana (n=1,172; 23.48%) residents using descriptive statistics and chi-square tests. Results: Male donors (n=58) were excluded from the analysis as no out-of-state collections have occurred since enrollment of men began in 2022. Age at donation varied significantly (p-value<0.001), with more Indiana donors under the age of 40 at donation (38.03%) compared to outside of Indiana (33.79%). Most donors identified as non-Hispanic white (75.44% Indiana, 67.66% non-Indiana), followed by non-Hispanic Black (17.75% Indiana, 14.68% non-Indiana), and Hispanic (6.44% Indiana, 13.99% non-Indiana). Indiana donors were more likely to have a high school degree/GED or less compared to non-Indiana residents (14.96% vs. 3.36%). Indiana participants had higher rates of ever having used cigarettes (19.00% vs. 5.81%), while alcohol use was also slightly less common (75.02% vs. 78.07%, p-value-=0.03) among Indiana residents versus non-residents. Note that smoking is MORE common among Indiana residents, but drinking is slightly LESS common. Other breast cancer risk variables were similar regardless of residence. Donors living outside of Indiana were more likely to be nulliparous, but overall number of children among parous women was similar. Breastfeeding did not differ by residence (p-value=0.08). Menopause status was also similar (p-value=0.08), as was BRCA mutation status (p-value=0.71). A family history of breast or ovarian cancer in a first-degree relative was reported by over half of both groups (52.04% Indiana, 52.02% non-Indiana). A prior, clinically indicated breast biopsy was reported slightly more often among non-Indiana women, which is likely related to their older ages at donation (22.78% vs. 19.51%, p=0.01). Conclusion: KTB participants demonstrate geographical differences in demographic and lifestyle factors but are more similar with respect to clinical factors that impact breast cancer risk. These insights underscore the importance of multisite tissue banking and highlight the success of targeted recruitment in the state of Indiana. Citation Format: Katherine E. Ridley-Merriweather, Vidya Patil, Teresa M. Imburgia, Jenny Cui, Colin Ferguson, Hannah Mandle, Michele L. Cote. Biobanking healthy tissue in the Susan G. Komen tissue bank: Comparing Indiana and non-Indiana residents [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr A072.