Brimonidine Topical Eye Drops and Intravitreal Administration Inhibit Form-Deprivation Myopia in Guinea Pigs: Ocular Pharmacokinetics and Irritation
At the drug concentrations in this study, both topical and intravitreal brimonidine achieved sufficient ocular exposure to exert similar myopia-suppressing effects. Continuous topical administration can maintain higher drug concentrations in the retinal and scleral tissues with less eye irritation.
Authors
- Susan S. Huang (ORCID: https://orcid.org/0000-0001-6748-3447)
- Xingwu Zhong (ORCID: https://orcid.org/0000-0002-1358-6544)
- Fang Zeng
- Yanting Luo (ORCID: https://orcid.org/0000-0002-6054-3301)
- Guofu Huang
- Hong He (ORCID: https://orcid.org/0000-0002-5604-7620)
- Junming Yang
Institutions
- Sun Yat-sen University (CN)
- Hainan Eye Hospital (CN)
Publication Details
- Journal
- Journal of Ocular Pharmacology and Therapeutics
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1177/10807683251376438
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00