Development of a submit candidate vaccine for the prevention of Dengue fever using immunoinformaics methods

The prediction of epitopes was carried out. The structural stability of the candidate vaccine was studied by the molecular dynamics method using the Gromacs-2023 software package. The results showed the preservation of the structural stability of all the studied subdomains. The final stage was the simulation of the cellular immune response using the C-IMMSIMM program. The results predict the ability of candidate vaccines to elicit both a vibrant primary and persistent secondary immune response.