Abstract B062: Multi-stakeholder partnership to identify and address research priorities in the early detection of prostate cancer among Black Americans

Abstract Introduction: Black prostate cancer patients are twice as likely to die compared to their peers. Yet, few national interventions/research studies exist to close this gap. We present a patient-centered approach to identify research priorities among Black prostate cancer patients and caregivers. Methods: We utilized the Black and African-descent Collaborative for Prostate Cancer ACtion (BACPAC) Virtual Research Community (VRC, n = 2,105) to conduct a research prioritization survey around prostate cancer early detection. Two rounds of surveys were conducted. In the first round, respondents were asked to rate the importance of 15 research topics identified by prostate cancer survivors and thought-leaders (5-point Likert scale). In a second round of surveys, participants were asked to prioritize a single topic based on the top two focus areas identified in the round 1 survey, and to answer questions about trial design/participation. VRC members were eligible to complete the online survey if they were a Black prostate cancer survivor or a relative/caregiver of a Black survivor. Results: 1,214 surveys were completed out of 1,557 eligible VRC members invited (78.6% response rate) in the first round. 62% of respondents identified as a Black prostate cancer survivor. More than 80% of respondents rated each of the 15 research topics as moderately to very important. Topic rankings revealed two overarching priority areas: 1) the use of reflex testing in the setting of elevated PSA and 2) establishing optimal timing and frequency of PSA screening. Second round participants (n = 407) identified “establishing optimal timing of initiating and frequency of PSA screening” as the top research priority. The majority of respondents (79.8%) expressed willingness to randomize in a study comparing screening to no screening. Respondents noted that the top barriers to participating in a screening trial would include cost (44.6%), confidentiality/privacy (39.6%), lack of insurance coverage (35.8%), concern about data use (35%), and research team trustworthiness (33.5%). Conclusion: Our survey identified critical research topics of high importance to Black prostate cancer survivors and their families/caregivers in the early detection of prostate cancer. We aim to address the top research priority prospectively in partnership with our multi-stakeholder team of survivors, clinicians, and researchers Citation Format: Jenney Lee, Sung Min Kim, Erika Wolff, Yohali Burrola-Mendez, Dante' Morehead, Ben Young, Raymond Miller, Robert Ginyard, Frank Fields, Marty Chakoian, Patrick Bingham, Daniel VanArsdale, Mike Crosby, Anthony Minter, Thomas Farrington, John Masembe, Burcu Darst, Ruth Etzioni, Adam Murphy, Samuel Washington, Jonathan Shoag, Ray Tan, Jeff Tosoian, Sarah Holt, Yaw Nyame. Multi-stakeholder partnership to identify and address research priorities in the early detection of prostate cancer among Black Americans [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr B062.