Abstract A112: Sociodemographic predictors of moderate-to-vigorous physical activity in a large nationwide US cohort

Abstract Introduction: Engaging in regular moderate-to-vigorous intensity physical activity (MVPA) is associated with lower risk of at least 7 types of cancer, yet nearly one-fourth of U.S. adults report engaging in no MVPA, with notable disparities by race, ethnicity, socioeconomic status, and geographic region. These disparities may be influenced by a lack of access to proper resources and/or environments that encourage exercise engagement. Additionally, poverty income ratio (PIR) has received little consideration, yet could provide deeper socioeconomic context than household income alone. Purpose: To investigate how race/ethnicity and sociodemographic factors are associated with adherence to the American Cancer Society’s cancer prevention guidelines for MVPA. Methods: Participants from the Cancer Prevention Study-3, a large U.S. cohort of cancer-free adult ages 30-65 years at enrollment (2006-2013), who self-reported moderate-to-vigorous physical activity on the 2018 follow-up survey were included. MVPA was calculated as MET hours/week (MET-h/wk) and categorized as: none [0 MET-h/wk, referent (ref.)], less than guidelines (>0 - <7.5 MET-h/wk), meeting guidelines (7.5–15 MET-h/wk), and exceeding guidelines (>15 MET-h/wk). Age (ref.) <50 years), urban/rural status (ref. metropolitan), race/ethnicity (ref. White), PIR (ref. high income ratio), education level (ref. graduate school), and marital status (ref. married) in relation to MVPA guideline adherence were assessed using multi-variable adjusted ordinal logistic regression. Results: In total, 150,400 participants [mean ± standard deviation or %] were included with the following characteristics: age: 55 ± 10 years, 79% female, 87% White/non-Latino, body mass index: 27.7 ± 6.3 m/kg2], 47% of whom met or exceeded guidelines in 2018. Women had lower odds of being in a higher MVPA category compared to men (OR= 0.59, 95% CI = 0.58, 0.60). Among women, lower odds of being in a higher MVPA category were seen in those who lived in micropolitan (OR=0.89, 95% CI: 0.86–0.93) or rural areas (OR=0.91, 95% CI: 0.87–0.96), were unmarried (OR=0.97, 95% CI: 0.94–0.99), aged > 65 years (OR=0.87, 95% CI: 0.85–0.90), or had lower PIR (below poverty: OR=0.63; low: OR=0.71; moderate: OR=0.81; all p<0.001). Race/ethnicity was not a significant factor among women. Among men, lower odds of being in a higher MVPA category were seen in those who were Asian/Pacific Islander (OR=0.82, 95% CI: 0.71–0.93), aged > 65 years (OR=0.93, 95% CI: 0.88–0.98), or had lower PIR (below poverty: OR=0.46, 95% CI: 0.37-0.56; low: OR=0.71, 95% CI= 0.61-0.82; moderate: OR=0.84, 95% CI=0.80, 0.89). Conclusion: Factors significant to women included rurality, marriage status, PIR, and age. Factors significant to men included race/ethnicity, PIR, and age. These factors underscore the need for targeted interventions, equitable resource allocation, built environment improvements, and further research into structural determinants of physical activity. Citation Format: Jamal R. Winn, Lauren Bates-Fraser, Sicha Chantaprasopsuk, Alpa V. Patel, Erika Rees-Punia. Sociodemographic predictors of moderate-to-vigorous physical activity in a large nationwide US cohort [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr A112.