Abstract A041: Mutation difference between African American, Asian and White lung adenocarcinoma patients

Abstract In this study we used mutations data from 22,300 patients with lung adenocarcinoma to test the frequency of TP53 mutations among African American (AA), Asian and White populations. The TP53 mutation frequency was similar between the AA and White populations (47.91%, 48.17%, and 43.67%), but the distribution and frequency of hotspot mutations were different. The TP53 R158 and R273 hotspot mutations were more frequent in AAs, R273 mutations were the most prevalent in the Asian population, and R273 and R248 mutations were the most notable in the Whites. When we tested the frequency of EGFR mutations among the races, as expected, we found the highest frequency of EGFR mutations in Asian populations (53.9%). Next, we compared the frequency of KRAS mutations among races. It was higher in the White population (32.62%) than the Asian (16.83%) and the AA (17.46%). The distribution of hotspot mutations is also different. The frequency of KRAS Q61H was higher in the AA (28.36%) than in the Asian (1.99%) and the White (1.66%) population, whereas KRAS G12I/L/N/Y mutations were observed in the White, but KRAS G12I/L/N/Y mutations were not observed in the AA and the Asian populations. In conclusion, our data indicates that genomic difference exists among the races in lung adenocarcinoma. Citation Format: Musaffe Tuna, Christopher I. Amos, Gordon B. Mills. Mutation difference between African American, Asian and White lung adenocarcinoma patients [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr A041.