Abstract B038: A pre- and post-evaluation of familiarity, intention, and knowledge about clinical trials following implementation of community-based clinical trial education sessions

Abstract Purpose: The ACT WONDER2S is a multilevel intervention to reduce barriers to cancer clinical trial (CCT) participation among Black/African American (BAA) and Hispanic (HS) populations. One intervention component includes Community Health Educator (CHE)-led CCT education sessions deployed in pre-identified geographic areas based on population composition and distance from the center. Preliminary outcomes are presented from CHE-led CCT education sessions aimed at using an educational presentation designed by the NCI and adapted to our community. This abstract evaluates changes in CCT familiarity, intent to participate, and knowledge, using pre- and post-session assessments. Methods: Four CHEs delivered CCT education sessions across seven geographically defined priority zones—areas with higher proportions of BAA and HS residents—within Moffitt Cancer Center’s catchment area. Sessions were held at community sites such as community centers and libraries. Familiarity with CCTs was measured with 2 items (scale 1–5), intention to participate (5 items, scale 1–5), and knowledge (11 items, scale 0–1). Mean scores were summarized for each of the three domains and subsequently re-scaled to 100 percent to facilitate analysis and results interpretation. Non-parametric pair-wise tests were used to assess improvement in the three domains related to CCTs from pre- to post-sessions. Results: Between September 17, 2024, and May 29, 2025, 16 CCT sessions were held with 210 participants;12% were BAA, 56% HS, 2% American Indian or Alaska Native, and 0.5% Asian. Familiarity scores increased from a mean of 58.7 (SD=21.8) pre-session to 73.3 (SD=18.8) post-session (p < 0.0001). Intention scores rose from 66.1 (SD=16.8) to 69.8 (SD=18.6; p < 0.0001). Knowledge scores showed a small increase from 81.0 (SD=16.6) to 82.5 (SD=16.0) (p = 0.36). Conclusion: The CHE-led CCT education sessions increased both familiarity with and intention to participate in clinical trials. The improvements observed in these areas highlight the value of culturally targeted education in addressing misconceptions and intention to participate regarding CCT participation, while improvements in knowledge were smaller and nonsignificant. These results represent data from the first 8 months of a 24-month intervention period; initial findings demonstrate promise for this approach to community clinical trials education that may serve to foster trust and promote equitable representation in clinical research. Citation Format: Christian Church, Yayi Zhao, Delilah Hernandez, Natasha Staley, Juanita Carbajal, Rossybelle Amorrortu, Lindsay Fuzzell, Elliott Tapia-Kwan, Melany Garcia, Barney Morris, Dana Rollison, Susan Vadaparampil. A pre- and post-evaluation of familiarity, intention, and knowledge about clinical trials following implementation of community-based clinical trial education sessions [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr B038.