Abstract A151: Fib-4 score correlations with lifestyle and health factors in a high-risk, diverse population: Baseline findings from a randomized tailored disease management intervention for hepatocellular carcinoma (HCC) prevention

Abstract Purpose: Hepatocellular carcinoma (HCC) represents a critical global health concern, with Texas experiencing a disproportionately high incidence across all major racial groups. HCC prognosis is often poor, primarily due to delayed detection and limited therapeutic options. Preventing HCC by addressing risk factors is crucial. This study evaluates the efficacy of a tailored, behaviorally focused disease management intervention for individuals presenting with fibrosis, steatosis, or cirrhosis risk factors and examines associations of High FIB-4 scores and demographic and lifestyle factors. Methods: This study was conducted at HOPE Clinic in Houston, Texas, which serves a racially, ethnically, and economically diverse patient population, many of whom are uninsured and at high risk for HCC. Patients with evidence of fibrosis or steatosis were included. A multi-level data collection approach included baseline surveys capturing demographics, physical and mental health, physical function, alongside clinical assessments such as the six-minute walk test, sit-to-stand test, FibroScan, and blood work. FIB-4 scores were calculated using complete blood count (CBC) and comprehensive metabolic panel (CMP) results. This analysis focused on baseline surveys and clinical assessments from 50 participants. The T-test and correlational analysis examined associations between FIB-4 scores and demographic factors (age, race, sex), as well as physical and mental health, function, and activity, measured via the PROMIS, Godin Questionnaire, and moderate-to-vigorous physical activity (MVPA) minutes. Results: FIB-4 scores showed no significant differences by race (p = 0.697), sex (p = 0.813), or education (p = 0.631) and were not associated with functional or anthropometric measures, including the six minute walk (p = 0.435), sit to stand (p = 0.987), BMI (p = 0.632), or waist hip ratio (p = 0.200). No significant correlations were observed with lifestyle or engagement measures, including PAM (p = 0.517), MMAS-8 (p = 0.424), or Godin scores (p = 0.421), nor with quality-of-life indicators such as PROMIS Global Health - Mental Health (p = 0.452), Physical Health (p = 0.392), and Physical Function (p=0.744). However, FIB-4 scores were significantly associated with Systolic Blood Pressure (p = 0.003). Conclusion: This study identified a significant association between FIB-4 scores and elevated blood pressure levels (p = 0.003), suggesting a potential link between liver fibrosis risk and elevated blood pressure, emphasizing the interrelationship between liver fibrosis risk and other chronic diseases related to lifestyle factors. While no significant correlations were observed with quality-of-life indicators, the relationship between SBP and liver fibrosis risk warrants further investigation. Ongoing follow-up, including 6- and 12-month assessments, will allow for evaluation of longitudinal changes in FIB-4 scores, lifestyle, and metabolic health indicators, offering insight into the impact of tailored interventions on liver health outcomes in this high-risk population. Citation Format: Syeda Fatima Sanaullah, Natalia I. Heredia, Che Young Lee, Jessica Hwang, Andrea Caracostis, Chrystial Correa, Johannah Abraham, Thuan Le, Tuate White, Kara Green, Karen Basen-Engquist. Fib-4 score correlations with lifestyle and health factors in a high-risk, diverse population: Baseline findings from a randomized tailored disease management intervention for hepatocellular carcinoma (HCC) prevention [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr A151.