β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE−/− mice
β-sitosterol ameliorates AS by attenuating lipid accumulation, inflammation, and oxidative stress via coordinated regulation of the MAPK/Nrf2/NLRP3 pathways. These findings highlight its potential as a therapeutic agent, though clinical studies are warranted to confirm efficacy and safety in humans.
Authors
- Chunsheng Qu (ORCID: https://orcid.org/0000-0002-7734-9302)
- Wugao Liu
- Weihua Chu (ORCID: https://orcid.org/0000-0003-0055-2035)
- Ningjun Wu
- Weiping Wu
- Jing Jin (ORCID: https://orcid.org/0009-0004-6153-1558)
Institutions
- China Pharmaceutical University (CN)
- Lishui Central Hospital (CN)
- Lishui City People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1371/journal.pone.0332990
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00