Reward network mechanism in anhedonia and depression
The current study is among the first to confirm that RMD patients possess different RN pattern compared with MDD. Importantly, caudate playsa unique role in depression remission, AC and thalamus mechanisms are trait-like markers of depression. Surprisingly, insula and inferior frontal mechanisms share by depressive episode and anhedonia, while putamen discriminates depressive episode and anhedonia. The results suggest candidate biomarkers for the treatment of clinical depression.
Authors
- Xiaoxiao Sun (ORCID: https://orcid.org/0000-0002-0823-8713)
- Jin Chen (ORCID: https://orcid.org/0000-0003-1297-6687)
- Qin Dai (ORCID: https://orcid.org/0000-0002-5831-7882)
- Zhaohua Chen (ORCID: https://orcid.org/0000-0002-8895-5236)
- Chun Cui
Institutions
- Army Medical University (CN)
- People's Liberation Army 401 Hospital (CN)
- Xinqiao Hospital (CN)
- Southwest Hospital (CN)
- Chongqing University of Technology (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1371/journal.pone.0332816
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43