1206 genomes reveal origin and movement of <i>Aedes aegypti</i> driving increased dengue risk
The emergence and global expansion of <i>Aedes aegypti</i> puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies <i>Ae. aegypti aegypti</i> (<i>Aaa</i>) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa <i>Aaa</i> migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that <i>Aaa</i> movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.
Authors
- Kevin Maringer (ORCID: https://orcid.org/0000-0003-0977-8807)
- Wei‐Liang Liu (ORCID: https://orcid.org/0000-0002-1159-1286)
- Darío Balcazar
- Andrea Gloria‐Soria (ORCID: https://orcid.org/0000-0002-5401-3988)
- Luciano V. Cosme (ORCID: https://orcid.org/0000-0003-4058-3274)
- Eric R. Lucas (ORCID: https://orcid.org/0000-0003-3892-1668)
- Aboubacar Sombié (ORCID: https://orcid.org/0000-0003-2833-4718)
- Sinnathamby N. Surendran (ORCID: https://orcid.org/0000-0002-7861-2037)
- Noah H. Rose (ORCID: https://orcid.org/0000-0001-7129-4753)
- Susanne Kluh (ORCID: https://orcid.org/0000-0001-6885-7535)
- Ademir Jesus Martins (ORCID: https://orcid.org/0000-0001-5739-1215)
- Chun‐Hong Chen (ORCID: https://orcid.org/0000-0002-3028-5508)
- Athanase Badolo (ORCID: https://orcid.org/0000-0002-6652-4240)
- Kim Y Hung (ORCID: https://orcid.org/0000-0002-2244-1806)
- Jennifer A. Henke (ORCID: https://orcid.org/0009-0006-9560-1643)
- Peter Armbruster (ORCID: https://orcid.org/0000-0002-8183-3842)
- Seth Redmond (ORCID: https://orcid.org/0000-0003-2653-760X)
- Carolyn S. McBride (ORCID: https://orcid.org/0000-0002-8898-1768)
- Jacob E. Crawford (ORCID: https://orcid.org/0000-0002-6745-9145)
- Isra Wahid (ORCID: https://orcid.org/0000-0002-6642-1401)
- Evlyn Pless (ORCID: https://orcid.org/0000-0002-6402-3397)
- Ashwaq M. Al-Nazawi (ORCID: https://orcid.org/0000-0001-9528-1893)
- David Weetman (ORCID: https://orcid.org/0000-0002-5820-1388)
- María Victoria Micieli (ORCID: https://orcid.org/0000-0003-0616-2214)
- Bradley J. White (ORCID: https://orcid.org/0000-0002-6444-4159)
- Henry A. Youd (ORCID: https://orcid.org/0009-0009-7666-6953)
- Jeffrey R. Powell (ORCID: https://orcid.org/0000-0002-7651-5153)
- Rusdiyah Sudirman Made Ali (ORCID: https://orcid.org/0000-0002-3988-9252)
Institutions
- University of California, Riverside (US)
- The Pirbright Institute (GB)
- Université Joseph Ki-Zerbo (BF)
- Los Angeles County Department of Public Health (US)
- National Health Research Institutes (TW)
- Georgetown University (US)
- Liverpool School of Tropical Medicine (GB)
- University of Jaffna (LK)
- Princeton University (US)
- Connecticut Agricultural Experiment Station (US)
- Yale University (US)
- Centro Científico Tecnológico - La Plata (AR)
- National Nuclear Energy Agency of Indonesia (ID)
- National Research and Innovation Agency (ID)
- Fundação Oswaldo Cruz (BR)
- Universidad Nacional de La Plata (AR)
- Jazan University (SA)
- Hasanuddin University (ID)
Publication Details
- Journal
- Science
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1126/science.ads3732
- Citations
- 9
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 16.91