Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis
Enrichment and activation of TBK1 in tumor-associated microglia upregulates GM-CSF to promote metastatic properties of breast cancer cells, highlighting TBK1 inhibition as a potential therapeutic opportunity for treating breast cancer brain metastasis.
Authors
- Fatima Khan (ORCID: https://orcid.org/0000-0002-8860-0339)
- Changiz Geula (ORCID: https://orcid.org/0000-0002-9311-3295)
- Peiwen Chen (ORCID: https://orcid.org/0000-0002-8129-9328)
- Edgar Petrosyan (ORCID: https://orcid.org/0000-0002-2543-3617)
- Maciej S. Lesniak (ORCID: https://orcid.org/0000-0002-0096-5107)
- Erfan Taefi (ORCID: https://orcid.org/0000-0002-7258-7483)
- Yang Liu (ORCID: https://orcid.org/0009-0003-6585-0145)
- Atousa Bahrami (ORCID: https://orcid.org/0009-0003-0515-7605)
Institutions
- Northwestern University (US)
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- University Hospitals Seidman Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1791
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00