Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i> -Mutant Lung Cancer
UXS1 loss in KEAP1-mutant cells causes pyrimidine nucleotide depletion, DNA replication stress induction, and ultimately cell-cycle exit that results in tumor stasis, highlighting UXS1 as a potential therapeutic target in KEAP1-mutant tumors. See related commentary by Yasseen and DeNicola, p. 4582.
Authors
- Bryson D. Bennett (ORCID: https://orcid.org/0009-0001-4640-1796)
- Nianxin Yang (ORCID: https://orcid.org/0000-0002-6842-7874)
- Aaron Boudreau (ORCID: https://orcid.org/0009-0005-1710-7503)
- J. Brad Shotwell (ORCID: https://orcid.org/0000-0002-7758-146X)
- Timothy E. Hoffman (ORCID: https://orcid.org/0000-0001-8077-867X)
- Wayne R. Buck (ORCID: https://orcid.org/0000-0002-0698-2178)
- Kelly D. Foster-Duke (ORCID: https://orcid.org/0009-0005-9721-907X)
- Noel S. Wilson (ORCID: https://orcid.org/0009-0006-6812-2022)
- Putianqi Wang (ORCID: https://orcid.org/0009-0008-3386-9630)
- Sammy Villa (ORCID: https://orcid.org/0000-0002-7261-4787)
- Melat T. Gebru (ORCID: https://orcid.org/0000-0003-0155-7786)
- Jessica Gajda (ORCID: https://orcid.org/0000-0001-7841-6557)
- James Newton (ORCID: https://orcid.org/0009-0008-6849-6598)
- Ari J. Firestone (ORCID: https://orcid.org/0000-0001-9902-443X)
- Samantha E. Wildeboer
- David Stokoe (ORCID: https://orcid.org/0000-0002-6333-5364)
- Ngoc Vu (ORCID: https://orcid.org/0000-0002-5323-7146)
- Michael E. Kort (ORCID: https://orcid.org/0000-0003-3059-9790)
- Celeste M. Sandoval (ORCID: https://orcid.org/0009-0002-4520-2880)
- Fei Han (ORCID: https://orcid.org/0000-0001-5756-1106)
- Xiumin Wu (ORCID: https://orcid.org/0000-0001-5537-3021)
- Christian Grant (ORCID: https://orcid.org/0009-0004-9427-8958)
- Jonathan A. Hickson (ORCID: https://orcid.org/0009-0008-6619-4190)
- Eddie Folk (ORCID: https://orcid.org/0009-0003-1518-4762)
Institutions
- AbbVie (United States) (US)
- Enzo Life Sciences (United States) (US)
- Biomedical Research Models (United States) (US)
- Scorpion Therapeutics (United States) (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4887
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81