KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer
Generation of an autochthonous KRASG12C-driven pancreatic cancer model enabled elucidation of specific effects of KRASG12C during tumor development, revealing CD24 as an actionable adaptive mechanism in cancer cells induced upon KRASG12C inhibition.
Authors
- Dean Pan (ORCID: https://orcid.org/0000-0002-8574-3836)
- Jangho Park (ORCID: https://orcid.org/0000-0002-6151-5193)
- Yong Zhou (ORCID: https://orcid.org/0000-0002-0214-8151)
- Ronald A. DePinho (ORCID: https://orcid.org/0000-0002-5625-577X)
- David H. Peng (ORCID: https://orcid.org/0000-0003-0511-1888)
- Jun Yao (ORCID: https://orcid.org/0000-0003-1418-3576)
- Ching-Fei Li (ORCID: https://orcid.org/0000-0001-7844-7003)
- Yanqing Jin (ORCID: https://orcid.org/0009-0006-9132-5071)
- Elizabeth M. Park (ORCID: https://orcid.org/0000-0002-1670-2299)
- Wantong Yao (ORCID: https://orcid.org/0000-0002-0172-7530)
- Dan Zhao (ORCID: https://orcid.org/0000-0001-7066-9058)
- Er-Yen Yen (ORCID: https://orcid.org/0000-0003-2918-5419)
- Minghui Liu (ORCID: https://orcid.org/0000-0003-1430-7807)
- Matthew Vasquez (ORCID: https://orcid.org/0000-0001-9319-2686)
- Madelaine Skolastika Theardy (ORCID: https://orcid.org/0000-0003-2560-775X)
- Zhenzhen Xun (ORCID: https://orcid.org/0009-0007-3667-9771)
- Han Liang (ORCID: https://orcid.org/0000-0001-7633-286X)
- Abdelrahman Yousef (ORCID: https://orcid.org/0000-0001-7761-8149)
- Timothy P. Heffernan (ORCID: https://orcid.org/0000-0002-3166-8922)
- Mitsunobu Takeda (ORCID: https://orcid.org/0000-0001-9598-1259)
- Phuoc T. Nguyen (ORCID: https://orcid.org/0000-0002-2904-5582)
- Andrea Viale (ORCID: https://orcid.org/0000-0003-4328-1044)
- Stephanie S. Watowich
- Haoqiang Ying (ORCID: https://orcid.org/0000-0003-0616-2310)
- Zecheng Yang (ORCID: https://orcid.org/0000-0001-5325-6809)
- Xiaofei Wang (ORCID: https://orcid.org/0000-0001-8953-9050)
- Hong Zhao (ORCID: https://orcid.org/0000-0001-8991-7824)
- Yiming Cai (ORCID: https://orcid.org/0000-0003-3533-1953)
- Huamin Wang (ORCID: https://orcid.org/0000-0002-2038-5863)
- Yongkun Wei (ORCID: https://orcid.org/0000-0001-8998-5333)
Institutions
- Houston Methodist (US)
- University of New Mexico Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- Quantitative BioSciences (US)
- The University of Texas Health Science Center (US)
- The University of Texas Health Science Center at Houston (US)
- The University of Osaka (JP)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1158/0008-5472.can-25-2024
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80