The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic Cancer
PIN1 plays a critical role in the response of pancreatic stellate cells to TGFβ and can be targeted to attenuate myofibroblast activation and protumor cross-talk to suppress pancreatic cancer progression.
Authors
- Nicholas D. Kendsersky (ORCID: https://orcid.org/0009-0007-5586-8308)
- Zina P. Jenny (ORCID: https://orcid.org/0009-0008-9434-4299)
- Katherine R. Pelz (ORCID: https://orcid.org/0000-0003-2169-0613)
- Arslan Amer (ORCID: https://orcid.org/0000-0002-3290-0017)
- Kayleigh M. Kresse (ORCID: https://orcid.org/0000-0001-7949-248X)
- Motoyuki Tsuda (ORCID: https://orcid.org/0000-0003-2873-1449)
- Eric J. Carlson (ORCID: https://orcid.org/0000-0002-1217-0563)
- Madeline R. Kuhn (ORCID: https://orcid.org/0000-0002-7157-3389)
- Aaron R. Doe (ORCID: https://orcid.org/0000-0001-6650-2001)
- Jason M. Link (ORCID: https://orcid.org/0000-0002-6892-0431)
- Carl Pelz (ORCID: https://orcid.org/0000-0002-2235-880X)
- Amy S. Farrell (ORCID: https://orcid.org/0009-0008-4599-5423)
- Mara H. Sherman (ORCID: https://orcid.org/0000-0001-7826-3888)
- Koei Chin (ORCID: https://orcid.org/0000-0001-8061-7462)
- Andrew C. Adey (ORCID: https://orcid.org/0000-0001-7648-8717)
- Brett C. Sheppard (ORCID: https://orcid.org/0000-0002-2182-7547)
- Taylor S. Amery (ORCID: https://orcid.org/0009-0008-5007-4952)
- Trent Waugh (ORCID: https://orcid.org/0009-0001-0874-1482)
- Brittany L. Allen-Petersen (ORCID: https://orcid.org/0000-0002-7436-9412)
- Zinab O. Doha (ORCID: https://orcid.org/0000-0003-2952-9840)
- Kevin MacPherson‐Hawthorne (ORCID: https://orcid.org/0000-0002-2657-8762)
- Gabrielle S. Dewson (ORCID: https://orcid.org/0000-0002-0874-0607)
- Andrew J. Fields (ORCID: https://orcid.org/0000-0002-0853-8054)
- Isabel A. English (ORCID: https://orcid.org/0000-0002-0566-9585)
- Jennifer Eng (ORCID: https://orcid.org/0000-0003-1499-8417)
- Gabriel M. Cohn (ORCID: https://orcid.org/0000-0001-5901-2506)
- Anupriya Agarwal (ORCID: https://orcid.org/0000-0002-8319-6162)
- Kristof Törkenczy (ORCID: https://orcid.org/0000-0002-4869-7957)
- Rosalie C. Sears (ORCID: https://orcid.org/0000-0003-1558-2413)
- Vidhi M. Shah (ORCID: https://orcid.org/0000-0001-7934-978X)
- Megan A. Turnidge (ORCID: https://orcid.org/0009-0008-1241-4864)
- Ellen M. Langer (ORCID: https://orcid.org/0000-0003-0352-1859)
- Mary C. Thoma (ORCID: https://orcid.org/0000-0002-6856-9282)
- Colin J. Daniel (ORCID: https://orcid.org/0009-0008-1915-3660)
- Chloe L. Bowman (ORCID: https://orcid.org/0009-0002-0517-706X)
- Xiaoyan Wang (ORCID: https://orcid.org/0009-0006-9559-9221)
- Kyra A. Lindley (ORCID: https://orcid.org/0009-0009-5734-6292)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- Purdue University West Lafayette (US)
- Taibah University (SA)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3437
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00