Quantitative Cell Type–Specific Immunopeptidome Analysis of Macrophage and Tumor Coevolution Reveals Therapeutic MHC-I Peptides in Glioblastoma
Immunopeptidomic analysis identified altered expression of antigens during macrophage-tumor coevolution that could be targeted with an mRNA vaccine to significantly inhibit glioblastoma growth, revealing potential immunotherapeutic strategies for treating tumors.
Authors
- Forest M. White (ORCID: https://orcid.org/0000-0002-1545-1651)
- Yufei Cui (ORCID: https://orcid.org/0000-0003-3014-813X)
- Stefani Spranger (ORCID: https://orcid.org/0000-0003-3257-4546)
- Kenny Kwok Hei Yu (ORCID: https://orcid.org/0000-0002-2394-4990)
- Jonathan Dye (ORCID: https://orcid.org/0000-0003-2801-8053)
- Laura Maiorino (ORCID: https://orcid.org/0000-0001-8217-1337)
- Nouran S. Abdelfattah (ORCID: https://orcid.org/0000-0001-7481-5251)
- B.J. Kim (ORCID: https://orcid.org/0000-0001-8131-5255)
- Kien H Phuong
- Heidi M. Temple (ORCID: https://orcid.org/0009-0004-7437-7350)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4674
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80