Surgery-Induced Neutrophil Extracellular Traps Promote Tumor Metastasis by Reprogramming Cancer Cell Lipid Metabolism
Surgery stimulates formation of neutrophil extracellular traps that promote fatty acid oxidation to support survival of disseminated cancer cells and metastasis, indicating that targeting this inflammation-metabolism axis may prevent tumor progression.
Authors
- Ruiqi Yang (ORCID: https://orcid.org/0009-0006-8932-1426)
- Samer Tohme (ORCID: https://orcid.org/0000-0001-8770-9706)
- Hamza O. Yazdani (ORCID: https://orcid.org/0000-0002-3437-0339)
- Silvia Liu (ORCID: https://orcid.org/0000-0002-1840-9520)
- Stacy G. Wendell (ORCID: https://orcid.org/0000-0001-9083-6933)
- David A. Geller (ORCID: https://orcid.org/0000-0003-0735-1068)
- Celine Tohme (ORCID: https://orcid.org/0009-0005-9450-0763)
- Christof Kaltenmeier (ORCID: https://orcid.org/0000-0003-1615-7443)
- Tony Haykal (ORCID: https://orcid.org/0000-0002-0475-4833)
- Richard L. Simmons (ORCID: https://orcid.org/0000-0001-6735-9913)
- Zikang He (ORCID: https://orcid.org/0009-0007-0996-3347)
Institutions
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- McGowan Institute for Regenerative Medicine (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3393
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78