The Accuracy of Blood Nucleic Acid Testing to Predict BK Polyomavirus Nephropathy Varies by Clinical Context

Test performance of QNAT in transplant recipients varies markedly according to clinical context. A negative QNAT in surveillance programs reliably rules out BKVAN. However, although positive results confirm BKV reactivation, QNAT levels could not accurately distinguish tissue-invasive infection at any threshold value.

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Publication Details

Journal
Transplantation Direct
Published
2025-09-18
DOI
https://doi.org/10.1097/txd.0000000000001845
Primary Topic
Polyomavirus and related diseases
Type
article
Field-Weighted Citation Impact
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article

The Accuracy of Blood Nucleic Acid Testing to Predict BK Polyomavirus Nephropathy Varies by Clinical Context

Brian J. Nankivell
Transplantation Direct
Polyomavirus and related diseases
article

The Accuracy of Blood Nucleic Acid Testing to Predict BK Polyomavirus Nephropathy Varies by Clinical Context

Brian J. Nankivell
article en

Abstract

Test performance of QNAT in transplant recipients varies markedly according to clinical context. A negative QNAT in surveillance programs reliably rules out BKVAN. However, although positive results confirm BKV reactivation, QNAT levels could not accurately distinguish tissue-invasive infection at any threshold value.

Transplantation DirectVol. 11(10)
Westmead Hospital (AU)
Openalex Percentile: Top 65%
Polyomavirus and related diseases
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The Accuracy of Blood Nucleic Acid Testing to Predict BK Polyomavirus Nephropathy Varies by Clinical Context — Brian J. Nankivell · Transplantation Direct (2025) | TGRS Research Map | TGRS