Angiogenesis and Hypoxia Biomarkers Are Dysregulated in Progressive Multiple Sclerosis
Hypoxia-angiogenesis signals are dysregulated in PMS. Increased hypoxia and an insufficient angiogenic adaptive response may play a role in PMS pathophysiology and be a relevant pathway, both in understanding disease mechanisms and as a possible therapeutic target.
Authors
- Marcus Koch (ORCID: https://orcid.org/0000-0001-9972-5092)
- Rajiv W. Jain (ORCID: https://orcid.org/0000-0002-6300-4063)
- Carlos R. Cámara-Lemarroy (ORCID: https://orcid.org/0000-0003-0676-6675)
- Nicholas J. Batty (ORCID: https://orcid.org/0000-0001-5024-6533)
- Heather Yong (ORCID: https://orcid.org/0000-0002-8117-8366)
- S J Phillips
- Maria Goiko
- Mankarman Ghuman
Institutions
- University of Calgary (CA)
- Ontario Brain Institute (CA)
- Hotchkiss Brain Institute (CA)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1212/nxi.0000000000200477
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00