Metformin in necrobiotic xanthogranuloma
Necrobiotic xanthogranuloma (NXG) represents a rare granulomatous skin disease characterized by IFN-γ-activated macrophages with limited treatment options. This study shows that metformin not only suppresses IFN-γ-induced macrophage activation, but also induced clinical remission in a patient with NXG. These findings highlight metformin as a promising candidate for therapeutic repurposing in NXG.
Authors
- Manuel Huerta Arana
- Mario Fabri (ORCID: https://orcid.org/0000-0002-9586-2230)
- Kerstin Becker (ORCID: https://orcid.org/0009-0009-7897-7181)
- Jan‐Wilm Lackmann (ORCID: https://orcid.org/0000-0001-8182-8034)
- Luisa Bopp (ORCID: https://orcid.org/0000-0002-9089-5228)
- Esther von Stebut (ORCID: https://orcid.org/0000-0001-9802-9642)
- Amira Aloui
- Ramon I. Klein Geltink
- Henning Klapproth (ORCID: https://orcid.org/0000-0003-1966-3069)
- Muhammad Shehryar Hussain
- Iliana Tantcheva‐Poór
Institutions
- University of British Columbia (CA)
- University of Cologne (DE)
- Jena University Hospital (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- BC Children's Hospital (CA)
- University Hospital Cologne (DE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1093/bjd/ljaf370
- Primary Topic
- Infectious Disease Case Reports and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00