Progression of the estimated glomerular filtration rate in asphyxiated neonates undergoing therapeutic hypothermia during the first 10 days of life
Based on a pooled dataset in TH cases, we converted Scr centiles to eGFR centiles. Based on median values, this resulted in a polynomial function in TH cases, compared to healthy term neonates. This eGFR function enables precision pharmacotherapy for GFR-cleared drugs in this vulnerable population.
Authors
- Julia Macente (ORCID: https://orcid.org/0000-0002-4452-5867)
- Pieter Annaert (ORCID: https://orcid.org/0000-0003-3525-7351)
- John van den Anker (ORCID: https://orcid.org/0000-0003-0571-7492)
- Anne Smits (ORCID: https://orcid.org/0000-0002-0710-6698)
- Djalila Mekahli (ORCID: https://orcid.org/0000-0003-0954-6088)
- Karel Allegaert (ORCID: https://orcid.org/0000-0001-9921-5105)
Institutions
- Children's National (US)
- Erasmus MC (NL)
- European Resuscitation Council (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Pediatric Nephrology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1007/s00467-025-06957-1
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Onderzoeksraad, KU Leuven
- Vlaamse regering