Exploring the top 30 drugs associated with drug-induced thrombotic microangiopathy based on the FDA adverse event reporting system

Our comprehensive analysis of drug rankings and signal strengths associated with TMA in FAERS underscores the critical role of pharmacovigilance in identifying and understanding drug-induced TMA. These findings necessitate further research to validate the observed associations and to develop effective risk management strategies, ultimately improving patient outcomes. This study provides valuable evidence to support the accurate clinical identification of drug-related TMA.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-09-18
DOI
https://doi.org/10.3389/fphar.2025.1658963
Primary Topic
Complement system in diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring the top 30 drugs associated with drug-induced thrombotic microangiopathy based on the FDA adverse event reporting system

Yi Yin, Yuqi Fan, Fanmin Meng
Frontiers in Pharmacology
Complement system in diseases
article

Exploring the top 30 drugs associated with drug-induced thrombotic microangiopathy based on the FDA adverse event reporting system

Yi Yin, Yuqi Fan, Fanmin Meng
article en

Abstract

Our comprehensive analysis of drug rankings and signal strengths associated with TMA in FAERS underscores the critical role of pharmacovigilance in identifying and understanding drug-induced TMA. These findings necessitate further research to validate the observed associations and to develop effective risk management strategies, ultimately improving patient outcomes. This study provides valuable evidence to support the accurate clinical identification of drug-related TMA.

Frontiers in PharmacologyVol. 16
Shandong Provincial Hospital (CN), Central Hospital of Zibo (CN), Shandong First Medical University (CN)
Openalex Percentile: Top 73%
Complement system in diseases
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