Impact of licorice supplementation on cardiac biomarkers and histomorphological changes in rats
Licorice supplementation at doses of 50, 100, and 200 mg/kg/day did not significantly impact the levels of cardiotoxic biomarkers but mild histomorphological changes were observed in the cardiac tissues of rats. These findings suggest that while licorice is generally safe at these doses, its long-term use at high doses should be approached with caution.
Authors
- Rozana Othman (ORCID: https://orcid.org/0000-0002-8260-9252)
- Sudha Arumugam
- Siew-Keah Lee (ORCID: https://orcid.org/0000-0001-9299-6842)
- Jin Han (ORCID: https://orcid.org/0000-0003-2847-0197)
- M. Salleh
- Liu Yuzhu
Institutions
- Mahsa University (MY)
- Universiti Tunku Abdul Rahman (MY)
Publication Details
- Journal
- Journal of Complementary and Integrative Medicine
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1515/jcim-2025-0027
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56