Predictors of the intensity of the inflammatory response after radiofrequency ablation of liver metastatic lesions in colorectal cancer patients

Inflammatory reactions to surgical interventions pose a risk of postoperative complications and affect the further course of the disease in cancer patients. Determining of the inflammatory response intensity in ColoRectal Cancer (CRC) patients after RadioFrequency Ablation (RFA) of liver metastatic lesions will allow to determine the group of patients who need perioperative anti-inflammatory treatment. The aim of the study was to establish predictive factors of the inflammatory response intensity in CRC patients after RFA of liver metastases. The Systemic Inflammation Response Index (SIRI) and the diameter of the largest liver metastasis were considered as predictive factors of the inflammatory response intensity. High levels of these indicators were associated with a significant increase in the inflammatory mediators’ levels after RFA. Patients with a high SIRI also showed significant immune disorders that may affect the further course of the disease. One-dimensional analysis showed that the product of SIRI and the diameter of the largest metastatic lesion (SIRI×Dmax) has the most significant accuracy in predicting of the inflammatory response intensity. The threshold value of SIRI×Dmax for predicting a high-intensity inflammatory response was determined to be 25.5. The use of the predictor of the intensity of the inflammatory response proposed by us will make it possible to separate the group of patients who, after interventional treatment of CR metastases to the liver, will need closer surveillance with a reduction in the time intervals between follow-up examinations for timely detection of recurrence. Identification of patients who are expected to have a high inflammatory response intensity will allow timely prescription of anti-inflammatory therapy and limit the negative impact of surgery on the further course of cancer. Keywords: cancer patients, surgical treatment of metastases, systemic inflammatory response index.