Photo-triggered tandem cyclization of arylethynyl quinazolin-4(3<i>H</i>)-one for difluoroalkylated quinolino[2,1-<i>b</i>]quinazolines
A photoinduced cascade difluoroalkylation/cyclization reaction of arylethynyl quinazolin-4(3<i>H</i>)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-<i>b</i>]quinazoline derivatives <i>via</i> consecutive intramolecular dual cyclization processes. It features mild reaction conditions, a broad substrate scope and moderate to good yields.
Authors
- Yuntao Xia (ORCID: https://orcid.org/0000-0002-2037-4531)
- Jinwei Yuan (ORCID: https://orcid.org/0000-0002-4170-4894)
- Liangru Yang (ORCID: https://orcid.org/0000-0001-8645-5505)
- Dajun Xing (ORCID: https://orcid.org/0000-0002-6953-1198)
- Qiang Liu (ORCID: https://orcid.org/0000-0002-5451-4862)
- Yongmei Xiao (ORCID: https://orcid.org/0000-0002-8573-4171)
- Haibo Yao
- Weixian Lv
Institutions
- Shandong University (CN)
- Henan University of Technology (CN)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04514b
- Citations
- 4
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 3.74